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Gomez's boyfriend Justin Bieber was (where else?) right on her heels with four honors: Choice Music: Male Artist, Choice Male Hottie, Choice Twit and Choice TV: Villain for his guest stint on CSI.
Big honors also went to the Harry Potter film franchise, which nabbed seven awards and was saluted with a montage at the end of Sunday's awards ceremony.
Other multiple winners included The Vampire Diaries (five awards), The Twilight Saga: Eclipse (four), Bad Teacher (three), Glee (three), Gossip Girl (three) and Pretty Little Liars (three).
The show, which aired live on Fox, was notable for featuring Sean Kingston's first public appearance after his watercraft accident.
Demi Lovato, who entered treatment for "emotional and physical issues" in November, was also on hand to pick up the Choice Summer Song award for "Skyscraper." "You guys are what got me through this last year," she told the crowd.